Liver ischaemia-reperfusion injury

Adkinson, D., Hollwarth, M.E., Benoit, J.N., Parks, D.A., McCord, J.M. and Granger, D.N. (1986). Role of free radicals in ischaemia-reperfusion injury to the liver. Acta Physiol. Scand. 548 (Suppl.), 101-107. 

Jaeschke, H., Farhood, A. and Smith, C.W. (1990). Neutrophils contribute to ischaemia/reperfusion injury in rat liver in vivo. FASEB J. 4, 3355-3359. 

As stated at the beginning of this article, the liver is the most intensively studied animal tissue in biochemistry. In the context of the role of free radicals in human diseases, the liver is not obviously at centre stage, since heart disease and cancer are more important in the industrialized world than, for example, cirrhosis. Free-radical biochemistry of the liver will remain a fertile area of work, however, not least because so many original ideas and techniques are developed there and then applied to the study of other tissues. The increasing use of liver transplantation, following the acceptance of kidney and heart transplants as almost routine, will surely increase the interest in the study of ischaemia-reperfusion injury in... 

Another antioxidative enzyme that has been targeted to the liver is catalase (CAT). Suc-cinylation and mannosylation resulted in an increased accumulation of the protein in the non-parenchymal cells of the liver. Furthermore, the CAT derivatives reduced hepatic injury in an ischaemia/reperfusion injury model [56]. 

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