Iron, carbonyl compounds manganese group

Transition metal organometallic compounds such as manganese, chromium, and iron carbonyls by the intraperitoneal route, and nickel by inhalation (mice) or intravenously (rats), induced selective necrosis of the Clara cells (Haschek et al. 1982). The pulmonary toxicity of methylcyclopenta-dienyl manganese tricarbonyl, representative of this group of compounds, was enhanced by pretreatment with piperonyl butoxide, an inhibitor of the mixed-function oxidase system. 

Substances that catch fire spontaneously in air without an ignition source are called pyrophoric. These include several elements— white phosphorus, the alkali metals (group lA), and powdered forms of magnesium, calcium, cobalt, manganese, iron, zirconium, and aluminum. Also included are some organometallic compounds, such as ethyllithium (LiC2H5) and phenyllithium (LiQHj), and some metal carbonyl compounds such as iron pentacarbonyl, Fe(CO)5. Another major class of pyrophoric compounds consists of metal and metalloid hydrides, including lithium hydride, LiH ... 

The most studied reaction involves the replacement of carbonyl groups by tertiary phosphines. This proceeds most readily in the case of cobalt derivatives, manganese compounds must usually be heated, and iron compounds require irradiation (except in the case of entry 13). 

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