IRAK interleukin receptor-associated

This receptor family mediates the effects of interleukin 1, a major proinflammatory cytokine, and interleukin 18, and includes TLR receptors of macrophages like TLR2 which recognize peptigoglycans of gram-positive bacteria. These receptors are coupled to the cytosohc serine/threonine kinase IRAK (interleukin receptor-associated kinase). Following signals include the activation of transcription factors like NFk,B, or others via MAP kinases. 

Jurrmann N, Brigelius-Flohe R, Bol GF. 2005. Curcumin blocks interleukin-1 (IL-1) signaling by inhibiting the recruitment of the IL-1 receptor-associated kinase IRAK in murine thymoma EL-4 cells. J Nutr 135 1859-1864. 

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