Iproniazid phosphate

Iproniazid phosphate [305-33-9] M 277.2, m 178-179". Crystd from water and acetone. 

Crane, G. E. 1956, Further studies on iproniazid phosphate isonicotinil-isopropyl-hydrazine phosphate marsilid, J.Nerv.Ment.Dis., vol. 124, no. 3, pp. 322-331. 

In view of the theories of Spector and Willoughby regarding the role of monoamine oxidase inhibitors in preventing the destruction of an adrenalinelike substance in tissue injury, it is not surprising that other workers have also found that these drugs inhibit inflammation. Thus iproniazid phosphate and... 

Fio. 2. Effect of iproniazid on serotonin levels in whole mice after serotonin. Mice were pretreated with iproniazid phosphate (300 mg./kg.), and after 30 minutes received 80 mg./kg. of serotonin. Control animals received serotonin alone. At various time intervals the whole mice, including excreta, were assayed for serotonin. Each point represents three animals. (Taken from Udenfriend, S., Weissbach, H., and Bogdanski, D. F. 1957. J. Pharmacol. Exptl. Therap. 120, 255-260.)... 

Iproniazid phosphate is not in use any more due to the otrurrence of severe liver toxicity. Phenelzine is available as its sulphate as film-coated tablets (15 mg). Irreversible MAOIs are generally not recommended for children. 

---