Ipratropium bromide water

Since water molecules occupy regular positions within the lattice of a hydrate with a specific stoichiometry (e.g., 1 1 monohydrate, 2 1 dihydrate, 5 1 pentahydrate) to the solid, relatively large quantities of water are sorbed. Figure 3 shows a moisture uptake isotherm for ipratropium bromide [39]. This substance undergoes an apparent hydration of the crystal between 63% and 75% relative humidity. Above 75% relative humidity, approximately 4.6% water is sorbed (theoretical monohydrate is 4.4 g/g). Interestingly, as anhydrous ipratropium bromide is equilibrated for extended time periods (e.g., 2 months and 5 months respectively, as shown in Fig. (3), hydration of the crystal appears to occur at... 

Fig. 3 Water vapor sorption and desorption isotherms for ipratropium bromide at 20°C ( ), 2 month sorption (A), 5 month sorption ( ), 2 and 5 month desorption [Note All 2 month sorption results, except at 53% and 63% relative humidity, were verified at 5 months.]...

IPA-water system, evolving separation strategies for, 22 322-325. See also Water-IPA-hexane system (-)-Ipecoside, 2 84, 85 Ipratropium bromide, 4 360t Iproclozide, 73 49... 

Atrovent HFA (BI) Ipratropium bromide November 2004 HFA 134a, purified water, dehydrated alcohol, anhydrous citric acid Solution... 

Ipratropium Bromide. Ipratropium bromide, 3-(.Thy-droxy-l-oxo-2-phenylpnopoxy)-8-methyI-8-(l-methylethyl,-8-a/oniabicyclo[3.2.l oclanc bromide (Atrovent). is a quaternary ammonium derivative of atropine. It is freely soluM in water and ethanol but insoluble in chloroform and ether. The salt is stable in neutral and acidic solutions but lapiiU hydrolyzed in alkaline solutions. 

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