Ipomea violacea

Convolvulaceae Ipomea violacea Ergoline Ergotamine Ergine... 

Genest, K. Changes in ergoline alkaloids in seeds during ontogeny of Ipomea violacea, J..Pharm. Sci. 55, 1284 (1966). 

The flrst total synthesis of chanoclavine I acid (47), a major alkaloid in the seeds of Ipomea violacea (48), was completed by Somei et d. who employed the key intermediate 51 for the formation of chanoclavine I (36), and also for the synthesis of chanoclavine 1 acid (69). Compound 51 was oxidized with pyridinium chlorochromate in dichloromethane to give the aldehyde 53, which was further oxidized to the carboxylic acid 64 by employing sodium hypochlorite in the presence of 2-methyl-2-butene (49), as shown in Scheme 11. 

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