IPC synthase

Sakoh, H., Sugimoto, Y., Imamura, H., Sakuraba, S., Jona, H., Bamba-Nagano, R., Yamada, K., Hashizume, T., and Morishima, H., 2004, Novel galbonolide derivatives as IPC synthase inhibitors Design, synthesis and in vitro antifungal activities. Bioorg. Med. Chem. Lett. 14 143-145. 

Galbonolide A (rustmicin), a 14-membered macrolide inhibitor of IPC synthase... 

Khafrefungin, an IPC synthase inhibitor with a C22 aliphatic chain esterified to polar head group (an aldonic acid)... 

It was shown that the IPC synthase was induced upon differentiation,47 providing an important target for antiprotozoal therapy, since no equivalent mammalian enzyme is known. In this respect, biosynthesis of radioactive IPC by metabolic labeling of T. cruzi epimastigotes,66 trypomastigotes,69 and amastigotes47 could be used to study the action of potential inhibitors. Properties of the IPC synthase have been described,70 but in contrast to earlier results,47 the authors report no inhibition of the enzyme by aureobasidin. Elucidation of the structure of the T. cruzi enzyme would clarify its analogy with the yeast enzyme. 

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