Iothalamic acid

Some of the ionic iodinated substances used in CAT scans include amidotrizoates (salts of diatrizoic acid) and iothalamates (salts of iothalamic acid)J l The typical cations are sodium ion or meglumine (A-methyl-Z)-glucamine) ion (Fig. 10.1.1),... 

Tris(iothalamic acid) (12) Sodium iodomethamate (lodo g l) (e) ... 

Tris (iothalamic acid) (12) 5,5, 5"-(Nitrilotriacetyltriimino)-tris (2,4,6-trilodo-W-methyl-isophthalamic acid) 61.67... 

Toxic effects of sodium ions and hyperosmolality associated with monomeric ionic contrast agents are lessened when dimeric and trimeric contrast agents containing, respectively, six and nine iodine atoms per molecule are used. Both bis(iothalamic acid) (i.e., iocar-mic acid) and tris(iothalamic acid) produce fewer peripheral vasodilatation and reflex responses than does the monomer iothalamic acid (9). 

Figure 4 Enzymatic activity of breast tumor homogenate activity (106pmoimg protein) at different periods of incubation A=0min B = 10min C = 20min and D = at 20 min in the presence of pepstatin (P = split peptide, l = iothalamic acid (internal standard) and T = pepstatin). (Reprinted with permission from (1996) Journal of Chromatography B 6S3 125 Elsevier.)...

Fig. 4 Effect of the separation buffer type on stacking at a sample loading of 12% of the capillary volume. Top Borate buffer 210 mM, pH 8.6 bottom triethanolamine 160 mM, tricine 50 mM, pH 8.6 containing 10% acetonitrile. Separation of a mixture of weakly cationic and weakly anionic compounds in the same run doxepin (D, 50 mg/L), A -acetylprocainamide (N, 50 mg/L), quinine (Q, 20 mg/L), theophylline (T, 50 mg/L) and iothalamic acid (I, 20 mg/L) at 14 kV, 254 nm (M = Electro-osmotic flow).

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