Ion-Promoted Alcoholysis of Phosphates

1 Proof of Concept LGA Provided by a Cu Phenanthroline in the Solvolysis of Closely Positioned tri-, di-, and Monophosphates 

A quantitative estimate of the energy that can be provided by the interaction of the oxyanion of the ligand of the product (21 ) in binding Cu  

2 Bimolecular Catalytic Phosphate Cleavage Reactions where Metal Ion-Promoted LGA is Apparent 

Adapted from Inorg. Chem. 2012 51 3846—3854 with permission. Copyright 2012, American Chemical Society. 

While experimental studies provide important data from which one can draw mechanistic information, they cannot provide intimate information about the details of how molecular transformations occur, nor can they provide much information about what happens after the rate-limiting step 

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