Hypervalent iodine Subject

A Ritter-type alkylation has been used to alkylate benzopyrazole to form the corresponding (V-trifluoromethyl imines. The methodology uses electrophilic hypervalent iodines in the presence of catalytic amount of acid to activate acetonitrile, affording the N-2 alkylated trifluoromethyl imine in 57% yield as the kinetic product in the reaction. The N-2 substituted imine, when subjected to similar reaction conditions over longer reaction times, affords... 

For a summary of reviews and books on this subject up to 2002, see Wirth, T. in Topics in Current Chemistry, Vol 224, Hypervalent Iodine Chemistry-j- Modem Developments in Organic Synthesis, Wirth, T. Ed. Springer-Verlag Publishers Berlin Heidelberg 2003, Chapter 1, pp. 1-4. 

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