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Alkylations benzopyrazole

A Ritter-type alkylation has been used to alkylate benzopyrazole to form the corresponding (V-trifluoromethyl imines. The methodology uses electrophilic hypervalent iodines in the presence of catalytic amount of acid to activate acetonitrile, affording the N-2 alkylated trifluoromethyl imine in 57% yield as the kinetic product in the reaction. The N-2 substituted imine, when subjected to similar reaction conditions over longer reaction times, affords... [Pg.37]

Alkylation of benzopyrazole sodium salts with difluoromethyl bromide affords a mixture of difluorobromomethyl-alkylated products. A similar reactivity is displayed in the BOM protection of benzopyrazole using the butyl dicyclohexylmethylamine as the hase (eqs 28, 29). ... [Pg.38]

See other pages where Alkylations benzopyrazole is mentioned: [Pg.551]    [Pg.551]    [Pg.551]    [Pg.181]    [Pg.551]   
See also in sourсe #XX -- [ Pg.38 ]



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Benzopyrazoles

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