Radioligand iodinated

An iodinated radioligand that speeilically labels the agonist high affinity state of 5-HT2 serotonin receptors. J Med Chem 31 5-7, 1988. 

Glennon RA, Seggel MR, Soine WH, Lyon RA, Davis K, Titeler, M. [125I]-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane an iodinated radioligand that specifically labels the agonist high-affinity state of 5-HT2 serotonin receptors. J Med Chem 1988 31 5-7. 

Palacios JM, Waeber C, Bruinvels AT, Hoyer D. Direct visualization of sero-toninlD receptors in the human brain using a new iodinated radioligand. Mol Brain Res 1992 13 175-178. 

Figure 11. Comparison of cross reactivity to ti -THC antiserum using tritiated and iodinated radioligands...

There should be specific, saturable binding to the receptor, accompanied by pharmacological characteristics appropriate to the functional effects, demonstrable using a radioactive, eg, tritium or iodine-125, ligand to label the receptor. Radioligand binding assays (1,6) have become a significant means by which to identify and characterize receptors and enzymes (see Immunoassays Radioactive tracers). Isolation of the receptor or expression of the receptor in another cell, eg, an oocyte can be used to confirm the existence of a discrete entity. 

Lan R, Gatley SJ, Makriyannis A. Preparation of iodine-123 labeled AM251, a potential SPECT radioligand for the brain cannabinoid CB1 receptor. J Labelled Comp Radiopharm 1996 38 875-881. 

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