Involving Other Internal or External Functional Groups

Cyclizations Involving Other Internal or External Functional Groups 

There are two examples in which the carboxylic group is first reduced to an alcohol. In this manner a multistep transformation yielded kainic acid 7 with the correct configuration at all three chiral centers (82JA4978). A similar reaction afforded (-)- or (+ )-lram-2,5-dimethylpyrrolidine from L- or D-Ala (87TL2083). 

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