Involved in Toxicity Testing

TABLE 12-7 Termination of Mouse and Albino Rat by Euthanasia (by parenteral administration of pharmacological agents) 

Species Barbiturate Overdose Route Chloralhydrate Overdose Route Ketamine Overdose Route 

TABLE 12-8 Administration of Volume of Test Chemicals to Laboratory Mouse and Albino Rat 

Source Modified from Laboratory Animal Information Service and Centre, National Institute of Nutrition, Indian Council of Medical Research, Government of India, Hyderabad, India 

Major issues stem from the fact that toxicology is in a stage of rapid development, and the harmonization of testing approaches rests on skill and judgment, not necessarily on purely scientific criteria. Accordingly, the guidelines represent an agreed basic approach, which must serve as a foundation for future development 

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