Introduction to Physiological Models

Modeling starts to play an increasingly important role in medicine. For insulin infusion (Parker, 2001 Andersen and Hojbjerre, 2003 Bergman et al., 1981), respiratory systems (Hamalainen, 1992, 2000), heart rate fluctuations (McSharry et al., 2003), blood-pressure regulation (Isaka, 1993), prediction of epileptic seizures (McSharry et al., 2003) and the study of metabolic disorders, to name just a few, models have been reported. 

It is not the intent of this chapter to discuss physiological systems modeling in detail, but rather to show some differences with the modehng of chemical and biological systems. 

The reader who is unfamiliar with the field of physiological modeling is referred to the books of Baura (2002) and Khoo (2000). These two books give an excellent impression of physiological systems modeling and analysis. 

There are numerous articles on glucose-insulin modeling owing to its relevance for patients with diabetes mellitus. Diabetes is a chronic syndrome, characterized by insufficient insulin production in the pancreas or decreased insulin activity, resulting in increased blood 

Process Dynamics and Control Modeling for Control and Prediction. Brian Roffel and Ben Betlem. 

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