Introduction Principles of Controlled Drug Delivery

The treatment of disease states has traditionally involved the use of multiple daily dosing of a therapeutic agent using a conventional dosage form, e.g., tablets or capsules. Following administration, the drug is absorbed into the systemic circulation in a stepwi.se fashion involving  

Topical profile of the drug plasma concentration as a function of time following oral administration of two doses 

There arc several strategies by which controlled release dosage forms may be formulated, all of which 

One repeat action dosage form containing two doses 

One controlled release dosage form containing the same drug 

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