Introduction 5-aminolevulinate synthase and iron

An additional emerging possibility of regulation of heme biosynthesis in differentiating erythroid cells resides at the ALAS2 mRNA translational level. ALAS2 synthesis is intimately related to the availability of iron. An iron-responsive ele- 

At the crux of the molecular recognition between the two macromolecules are the IRE structure [30-32] and the multifaceted IRP structure [43]. IRPl is highly homologous to mitochondrial aconitase, a [4Fe-4S] cluster-containing protein, and it 

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