Chills intravenous immunoglobulin

The rate of adverse effects associated with intravenous immunoglobulin varies among different studies, which has been attributed to factors such as the indication, the dosage, the infusion rate, and the patient s age (12). In one study, headache and chills were related to a higher dosage. 

Of 56 patients with autoimmune diseases who received high dosages of intravenous immunoglobulin, 20 had at least one adverse effect after one or more courses of treatment (12). The most frequently reported adverse effects were low-grade fever, headache, and chills. The authors concluded that the occurrence of adverse effects with intravenous immunoglobulin was not related to the clinical response to treatment. However, patients who developed adverse effects during the first course of treatment were more at risk of adverse effects during subsequent courses. 

Mild adverse effects of intravenous immunoglobulin, such as headache, chills, nausea, backache, and flushing, occur at a rate of 5-10% (101,135). Most of these... 

Anti-D immunoglobulin is used as an alternative to intravenous immunoglobulin to treat idiopathic thrombocytopenic purpura. Patients treated with anti-D immunoglobulin (WinRho ), in contrast to earlier published reports, had more adverse reactions, particularly chills and rigors, despite pretreatment with paracetamol and diphenhydramine [66 ]. Two patients needed treatment for severe anemia and one for severe hemoglobinuria. Pretreatment with glucocorticoids or the use of subcutaneous anti-D immunoglobulin may reduce transfusion-related adverse reactions. However, the... 

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