Intrapulmonary distribution

Ganuna scintigraphy can provide visually striking pictures, an idea of total lung dose, and an indication of the likely intrapulmonary distribution when using... 

C. PET Imaging to Evaluate the Intrapulmonary Distribution of Transgene Expression... 

Gore DJ. 1983. The spatial and temporal distribution of inhaled U02 particles in the respiratory tract of the rat. II. The relative concentration of U02 between the intrapulmonary airways and the pulmonary tissue. Radiation Research 93 276-287. 

Markers of physiological effects can be useful in identifying early changes in respiratory functions of the lung due to inhaled material. Biomarkers are available to measure lung mechanical properties, ventilation, expiratory flow, intrapulmonary gas distribution, alveolar-capillary gas exchange, and perfusion. Such measurements have been used to test the effects of exposure to an array of inhaled toxicants. These assays can reveal functional manifestation of structural changes in the respiratory system, whether... 

Generic Products. Low-cost devices are marketed but can perform much worse with respect to intrapulmonary deposition than more expensive devices [72]. Common nebulizers are ubiquitous, as are compressors to operate them. Aerosol medications are marketed with recommendations for use with specific nebulizers and compressors for optimal results [73]. Nebulizers are commonly used for many weeks to months, even those devices described as disposable. When disposable devices are washed using saline, they maintain size distribution and output for at least 100 uses but, when not so cleaned, begin to deteriorate after 40 uses [74]. 

---