Intraportal administration

By comparing the systemic exposure of green tea catechins in rats after intravenous and intraportal administration, Cai et aU found that tea catechins do not undergo significant presystemic hepatic metabolism. Consistently, when EGCG was administered at a dose of 100 mg/kg to rats by intraperitoneal injection, much higher... 

Lundin S, Pierzynovski S G, Westrom B R, et al. (1991). Biliary excretion of the vasopressin analogue DDAVP after intraduodenal, intrajugular and intraportal administration in the conscious pig. Pharmacol. Toxicol. 68 177-180. 

Nagamine et al (55) estimated the rates of available fraction for 4-acetam1doacetophenone, 4-acety1benzene-sulfonamide, and acetohexamide and their respective reduced compounds, 4-subst1tuted o-hydroxyethylphenyl derivatives. In rats. The study Indicated that the compounds are in a reversible drug-metabolite relationship. The pharmacokinetic profiles of the agents were studied after an Intraportal administration... 

Schnell MA, Zhang Y, Tazelaar J, Gao G-P, Yu QC, Qian R, Chen S-J, Vamavski AN, LeClair C, Raper SE, Wilson JM. Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors. Mol Ther 2001 3 708-722. 

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