Intramolecular pseudo-high-dilution

The principle of oxidation of bis-cysteine peptides on resin consists of deprotection and oxidation of a cysteine pair in a single step or in two separate steps to form the disulfide bond while the peptide chain remains attached to the solid support. The strategy is especially effective for the formation of intramolecular disulfides since the solid support simulates high dilution via the pseudo-dilution effect, thus, largely preventing intermolecular reactions. 163 98 10° ... 

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