Intramolecular proteins

G. M. Whitesides, Dependence of effective molarity on linker length for an intramolecular protein-ligand system, /. Am. Chem. Soc., 129 (2007)... 

Krishnamurthy,V. M., Semetey,V.,Bracher,P.J., Shen, N., Whitesides, G. M. Dependence of Effective Molarity on Linker Length for an Intramolecular Protein-Ligand System. J. Am. Chem. Soc. 2007, 129, 1312-1320. 

Near-infrared excited FT-Raman spectroscopy has recently begun to show promise (Schrader, 1990), because the fluorescence is drastically reduced. It has the Jaquinot advantage over classical Raman spectroscopy, which affords a better signal-to-noise ratio. FT-Raman is an excellent technique to supplement FTIR difference spectroscopy in investigations of intramolecular protein reactions because Raman spectra have the... 

Some of the results of our MD simulations of proteins on clay mineral surfaces are summarized in Fig. 8-5. When proteins are placed in the interlayer space of clay minerals, interactions between the surface and the protein compete with intramolecular protein nonbonded interactions. As a result, a protein molecule can gel stretched out along the mineral surface, significantly denatured from its native stale. In the case ol mhredoxiii adsorbed by pyropliyllite. for example, the mole-... 

Abstract The assembly of the N-terminus heptad repeats of the respiratory syncytial virus (RSV) F protein into a trimeric complex that associates with the C-terminus heptad repeats to form a six-helix bundle is a critical step in the process of vims-host fusion and represents an intramolecular protein-protein interaction. Screening campaigns using replicating virus assays have identified several structurally distinct but mechanistically similar chemotypes that interfere with RSV fusion by disrupting the function of the F protein six-helix bundle. This chapter summarizes structure-activity relationships and mechanistic insights associated with the most prominent RSV fusion inhibitors and the key issues in the development of potential clinical candidates. 

Inhibitors of Respiratory Syncytial Virus Fusion Interfering with an Intramolecular Protein-Protein Interaction... 

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