Intramolecular interactions and

Page, M. L., Jencks, W. P. Entropic contributions to rate accelerations in enzymic and intramolecular interactions and the chelate effect. Proc. Natl. Acad. Sci. USA 68 (1971) 1678-1683... 

The relaxation data for the anomeric protons of the polysaccharides (see Table II) lack utility, inasmuch as the / ,(ns) values are identical within experimental error. Obviously, the distribution of correlation times associated with backbone and side-chain motions, complex patterns of intramolecular interaction, and significant cross-relaxation and cross-correlation effects dramatically lessen the diagnostic potential of these relaxation rates. 

Viviana, W., J.-L. Rivail, and I. G. Csizmadia. 1993a. Peptide Models n. Intramolecular Interactions and Stable Conformations of Glycine, Alanine, and Valine Peptide Analogues. Theor. Chim. Acta 85,189-197. 

The key in activation of Src family kinases is the disruption of intramolecular interactions and relief of autoinhibition. In addition to dephosphorylation of Y527 by PTPs, the SH2-phosphoY527 bond can be disrupted by competition with a high affinity phosphotyrosine ligand. 

The building blocks of supramolecular systems are held together by intramolecular interactions and these systems are reversible. This intrinsic property is not only a consequence of the more labile interactions within supermolecules, compared to covalent bonds in molecules, but reversibility is essential for the function expressed by supramolecular systems. Kinetics can never be inferred from thermodynamic studies. For example, the knowledge of a host-guest equilibrium constant does not... 

Fujimoto, H. and K. Fukui. 1974. Intramolecular interactions and chemical reactivity. In Chemical Reactivity and Reaction Paths, (Ed.) G. Klopman, pp. 23-54. New York Wiley-Interscience. 

A. J. Barnes, H. E. Hallam, and D. Jones, Vapour phase infrared studies of alcohols I. Intramolecular interactions and self association. Proc. R. Soc. London A 335, 97 111 (1973). 

The numerical efficiency of the viscosity lower bound method has allowed calculations on considerably longer chains. The long chain Hmit results for 12-arm stars without intramolecular interactions and with EV (up to 325 beads) and in the theta region (up to 145 beads) [164] are close to the previous estimates with shorter chains (the extrapolated ratio g obtained in this study is also included in Table 4). The lower bound method has also served to characterize globule-coil transitions of 12-arm star chains from intrinsic viscosity calculations [143], though finite size effects are considerably more important than in the characterization of this transition from the radius of gyration data (see Fig. 17). This is due to the noticeable increase in the solvent permeabiHty associated with the chain expansion in better solvent conditions. However, the permeability effects are smaller in the more compact star chains than in their linear counterparts. 

However, the consideration of intramolecular interactions and, therefore, of reahstic distributions of intramolecular distances changes the shape of the func-... 

Changes in the Inter- and intramolecular interaction and in the structure of carbanion pairs on adding cation-binding ligands (ethers, crown ethers, poly-amines) is briefly reviewed. 

Dielectric measurements are carried out on PPOA and PPODG. The dielectric spectrum of PPOA in the bulk presents a prominent glass-rubber relaxation followed by a subglass absorption. The low-molecular-weight compound only exhibits a prominent glass-liquid absorption followed by a diffuse and weak subglass relaxation. This behaviour cannot be explained in terms of only intramolecular interactions, and therefore intermolecular interactions must play an important role in this process. 

The conformation of a protein is dependent on weak intramolecular interactions and is also likely to change with varying pH. Therefore its function and its catalytic activity will be highly dependent on pH(,8). 

Fig. 8. Mechanisms by which agonist binding may change the relative arrangement of TM segments. (A) The agonist binding requires disruption of intramolecular interactions and the formation of new interactions with the ligand. (B) The agonist binds directly to amino acids involved in forming stabilizing intramolecular interactions.

Molecular mechanics calculations of 142 and 143 reveal that steric interactions between adjacent bulky alkyl chains force the C-9 and C-10 groups into conformations that are unlike artether 145. One might argue that these new conformations are unacceptable and can account for the drop in activity. However, the intermediate lactols should not suffer from these intramolecular interactions and should retain activity. Surprisingly, however, butyl-substituted lactol 141 (reduction product of 45) was found to be less active than dihydroartemisinin. 

M. G. Veselov, Current Problems in Quantum Chemistry Quantum Chemistry Methods in the Theory of Intramolecular Interactions and Solids. Collection of scientific proceedings, Nauka, Leningradskoe Otd., Leningrad, 1987. 

---