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Intramolecular, addition Mukaiyama aldol

A recent approach toward ( )-guanacastepene (rac-187) published by Kwon in 2003 employed a sequential methyl cuprate 1,4-addition to the en-one 281 followed by an intramolecular Mukaiyama aldol condensation to construct the B ring (Eq. 9) [142, 143] ... [Pg.131]

Auto-tandem hydroformylation-cyclization, catalyzed by [RhCl(cod)]2, enables expansion of the organic skeleton of unsaturated silyl enol ethers (Scheme 10). Linear aldehydes generated in the hydroformylation step subsequently undergo Rh-catalyzed, intramolecular Mukaiyama aldol addition. Bicyclic ketones are also accessible from cyclic silyl enol ethers. [Pg.462]

A formal [3 + 2]-cycloaddition reaction was developed featuring an aza-Cope rearrangement followed by an intramolecular Mukaiyama reaction to trap the resulting imine. Initially, compound 212 was prepared by a Mukaiyama aldol reaction between 210 and 211. This was followed by the 2-aza-Cope rearrangement of 212, resulting in 213. Following an intramolecular Mukaiyama aldol addition, 214 is produced in moderate yield. [Pg.121]

Under classical Mukaiyama conditions, silyl enol ether 2-372 and the Michael acceptors 2-373 and 2-374 underwent a twofold 1,4-addition to form an enolate in which an ideal set-up exists for an intramolecular aldol reaction. This led to 2-375 with the desired structural core of 2-376 in an overall yield of 42%. [Pg.107]

Intermolecular Michael addition [4.1] Intermolecular aldol reaction [6.2.1] Intramolecular aldol reaction [6.2.2] Aldol-related reactions (e.g. vinylogous Mukaiyama-type aldol) [6.2.3]... [Pg.438]

Lewis acid, by enolsilane addition to chiral oxonium ions (cf. equation 40). Oxonium ions are also probably involved in the diastereoselective AlCb-mediated additions of enolsilanes to chiral 2-benzenesulfo-nyl cyclic ethers. In the diastereoselective additions to chiral acetals - (see Section 2.4.4.4), an extension of the methodology shown in Scheme 9 to the enantio differentiation of meso 1,2- and 1,4-diols was reported. An intramolecular Mukaiyama acetal-aldol reaction (see Section 2.4.4.S) was reported as the key step to construct the 11-memboed ring of hydroxyjatrophone A and B. "... [Pg.657]


See other pages where Intramolecular, addition Mukaiyama aldol is mentioned: [Pg.518]    [Pg.84]    [Pg.446]    [Pg.9]    [Pg.389]    [Pg.394]    [Pg.134]    [Pg.92]    [Pg.167]    [Pg.657]    [Pg.657]    [Pg.92]    [Pg.119]   
See also in sourсe #XX -- [ Pg.1353 ]




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