Porosity intragranular

Void spaces created by the arrangement of the atoms in a crystal (structural porosity) this is then called intragranular porosity... 

Particle agglomeration is mainly influenced by the degree of liquid saturation which is, in turn, dependent on the intragranular porosity and volume of binder solution used. It was found that the primary factors affecting the density and porosity of lactose and calcium phosphate during high shear granulation were the amount of binder solution... 

FIGURE 8 Correlation between intragranular porosity and the percentage of binder solution added in a high shear granulator (impeller speed 4[Pg.288]

The effect of different levels of binder solution (PVP K-30 at 3%, and Methocel E5 from 3% to 8%) added during high-shear mixing on dicalcium phosphate porosity was reported earlier by Ritala et al. (113). They found that as the wet massing time increases and as the mean granule size increases with the addition of increased levels of binder, that the intragranular porosity decreases (86). 

Jaegerskou A, Holm P, Schaefer T, Kristensen HG. Granulation in high speed mixers. Part 3. Effects of process variables on the intragranular porosity. Pharm Ind 1984 46(3) 31CM. 

X-ray microcomputed tomography Internal structures such as density distribution maps in tablets, intragranular porosity, bone biomaterials 146-160... 

Agglomerates are in the pendular state when the liquid saturation of the pores S < 25% in the funicular state when S is between 25% and 80% and in the capillary state when S > 80 /o. The liquid saturation S is determined by the amount of binder solution and the intragranular porosity, which can be calculated based on the following equation (17) ... 

Lindberg NO, Tufvesson C, Holm P, Olbjer L. Extrusion of an effervescent granulation with a twin screw extruder. Baker Perkins MPF 50 D. Influence on intragranular porosity and liquid saturation. Drug Dev Ind Pharm 1988 14 1791-1798. 

The recognition of secondary intragranular porosity associated with feldspar grains is not a problem, but any identification of intergranular pores as being of secondary origin is interpretative and subjective, and is based on textural criteria established by Schmidt and McDonald (1979). Calcite cement may be dissolved to create secondary intergranular porosity that... 

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