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Intracellular trafficking apparatus

Poliovirus noncapsid protein 3A is a multifunctional viral protein involved in poliovirus RNA replication. One of its functions is suppression of protein trafficking between the ER and Golgi apparatus. In infected cells, it affects the intracellular trafficking of TNFR and induces TNF resistance by eliminating TNFRs from the plasma membrane. This 3A-protein-mediated inhibition of ER to Golgi traffic ofTNFR was limited to poliovirus and coxsackievirus B3. Further investigation is required to understand whether this inhibition is selective for TNFR or not. [Pg.73]

See other pages where Intracellular trafficking apparatus is mentioned: [Pg.19]    [Pg.52]    [Pg.118]    [Pg.156]    [Pg.573]    [Pg.55]    [Pg.472]    [Pg.4]    [Pg.167]    [Pg.87]    [Pg.1016]    [Pg.241]    [Pg.1016]    [Pg.2665]    [Pg.264]    [Pg.2664]    [Pg.176]    [Pg.94]    [Pg.91]   
See also in sourсe #XX -- [ Pg.148 , Pg.149 ]



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Trafficking

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