Interstitial basophils

Oosporein, which is produced primarily by Oospora colo-rans and Caetomium trilaterale, is observed in feed stuffs, cereals and peanuts. It has been reported to be toxic in poultry resulting in nephrotoxicity, and visceral and articular gout. The pathological observations in oosporein toxicity include necrosis of the tubular epithelial cells in the proximal tubules with basophilic casts, hyaline casts in the distal tubules with fibrosis and interstitial pyogranuloma-tous inflammation, urate deposits in various tissues, and proventricular enlargement with mucosal necrosis (Pegram and Wyatt, 1981 Brown et al, 1987). 

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