Interphotoreceptor retinoid binding protein

The interphotoreceptor retinoid-binding protein (Borst et al., 1989) functions in the regeneration of rhodopsin in the mammalian visual cycle. It is exclusive to vertebrates yet contains a repeated structure that has been found singly in bacterial and plant tail-specific proteases (TSPc) (Silber et al., 1992) and the archaeal tricorn protease (Tamura et al., 1996). The eukaryotic homologs of TSPc are likely to be inactive as... 

The pigment epithelium of the retina receives all- fraws-retinol fromplasma RBP. It is then isomerized to ll-c(s-retinol, which may either be stored as ll-c(s-retinyl esters or oxidized to ll-c(s-retinaldehyde, which is transported to the photoreceptor cells bound to an interphotoreceptor retinoid binding protein. 

Tschanz CL and Noy N (1997) Binding of retinol in both retinoid-binding sites of interphotoreceptor retinoid-binding protein (IRBP) is stabilized mainly by hydrophobic mtetActiom,. Journal of Biological Chemistry 272,30201-7. 

Retinal antigens, such as S-antigen (arrestin), interphotoreceptor retinoid-binding protein (IRBP), rhodopsin, recoverin, and phosduscin, appear to hold uveitogenic properties. Immunization with these antigens or their fragments can induce... 

Carlson, A., and Bok, D. (19%). I rornotion of the release of ll-ci s-retinal from cultured retinal pigment epithelium by interphotoreceptOr retinoid-binding protein. Biachemisiry 31, 9056-9062,... 

Chen, Y., Houghton, L.A., Brenna, J.T. and Noy, N. (1996) Docosahexaenoic acid modulates the interactions of the interphotoreceptor retinoid-binding protein with 11-cw-retinal. J. Biol. Chem. 271 20507-20515. 

Liou GI, Wang M, Matragoon S. 1994. Timing of interphotoreceptor retinoid-binding protein (IRBP) gene expression and hypomethylation in developing mouse retina. Dev Biol 161 345-356. 

Chen Y. Saari JC, Noy N. Interactions of all-frans-retinol and long-chain fatty acids with interphotoreceptor retinoid-binding protein. Biochemistry 1993 32 11,311-11,318. 

Measurement of Rates of Dissociation of Retinoids from the interphotoreceptor Retinoid-Binding Protein... 

Bazan, N. G., Reddy, T. S, Redmond, T, M., Wiggert, B, and Chader, G J (1985) Endogenous fatty acids are covalently and noncovalently bound to interphotoreceptor retinoid binding protein in the monkey retina J. Biol. Ghent. 260, 13,677-13,680... 

Saan, J C., Teller, D C, Crabb, J. W, and Bredberg, L (1985) Properties of an interphotoreceptor retinoid-binding protein from bovine retina J Biol Ghent 260, 195-201... 

Pepperberg DR, Okajima TL, Wiggert B, Ripps H, Crouch RK, Chader GJ (1993) The role of interphotoreceptor retinoid-binding protein (IRBP) in the visual cycle of rhodopsin. Mol Neurobiol 7 61-84 Chen Y, Noy N (1994) Retinoid specificity of interphotoreceptor retinoid-binding protein. Biochemistry 33 10 658-10 665... 

Lin Z-Y, Li G-R, Takizawa N, Si J-S, Gross EA, Richardson K, Nickerson J (1997) Structure-function relationships in interphotoreceptor retinoid-binding protein (IRBP). Molecular Vision 3 ... 

In order to address the possibility that the light effect might be artificially created by the tissue culture assay, in which the normal retina/RPE apposition is disrupted and the interphotoreceptor retinoid binding protein is washed away, we did experiments in which the only light... 

Interphotoreceptor retinoid binding protein (IRBP) occupies the space between the RPE and the rod outer segment (ROS), the interphotoreceptor matrix, and binds both llcROH and llcRCHO. Retinoids do not require IRBP for transfer between the two membranes, however, because IRBP null mice show no gross abnormalities of the visual cycle, even though they have severe retinal abnormalities. Although retinoids have very limited solubility in the aqueous phase, membranes of the RPE and ROS transfer retinoids between them in the absence of IRBP. 

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