International Conference mass balance

The assessment of degradation in pharmaceutical products involves two aspects of analytical measurement. First, a selective analytical method must be available for accurate assay of the parent drug compound, in order to correctly measure any loss. Second, methodology should be in place for quantification of the degradation products formed. Ideally, when degradation occurs, the measured amount of parent drug lost should correlate well with the measured increase in degradation products. This correlation is referred to as mass balance )- More recently, the International Conference on Harmonization (ICH) has provided a definition of mass balance material balance as follows ... 

Won D, Shaw CY, Biesenthal TA, Lusztyk E, Magee RJ (2002) Applications of chemical mass balance modeling to indoor VOCs. Proceedings of the 9th international conference on indoor air quality and climate. Monterey, CA, USA, p 268... 

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