Intermolecular Nitro-Michael Additions of -Nucleophiles

On the other hand, several other analogues of proline were also capable of inducing chirality for the Michael addition of various aldehydes to nitroalkenes. 

In 2009, Peng et al. reported the synthesis of chiral 4-trifluoromethane-sulfonamidyl prolinol zerz-butyldiphenylsilyl ether and its highly efficient application as an organocatalyst for the Michael addition of cyclohexanone to various nitroalkenes, providing almost quantitative yields combined to 

In addition, several supported chiral ionic liquids have been investigated for these reactions. Therefore, Wang et al. have developed a new type of polymer-immobilised pyrrolidine-based chiral ionic liquids, which were capable of inducing the Michael addition of ketones to nitrostyrenes in high yields. 

Michael additions of cyclohexanone to nitroalkenes catalysed by supported pyrrolidine-based ionic liquids. 

Other-than-proline derivatives have been successfully employed to catalyse a great number of asymmetric nitro-Michael reactions. Therefore, excellent 

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