Intermolecular Michael Additions of -Nucleophiles

1 Intermolecular Michael Additions of C-Nucleophiles Catalysed by Proline Derivatives 

Similar Michael additions of various aldehydes to vinyl sulfones to some of those depicted above have also been developed by Alexakis et al. in the presence of an aminal-pyrrolidine organocatalyst derived from proline, albeit leading to 

Silylated biarylprolinol-catalysed Michael additions of aldehydes to vinyl 

On the other hand, most organocatalysed Michael additions of stabilised carbon nucleophiles have involved either nucleophiles or electrophiles that are highly activated. As an example, Michael additions of highly activated nucleophiles, such as malonates, to a,p-unsaturated aldehydes have been reported. Therefore, Ma et al. have reported the Michael addition of malonates 

In 2008, Barbas et al. developed the first enantioselective thioester Michael addition of simple trifluoroethyl thioesters, thereby establishing a new class of nucleophiles for direct catalytic reactions. Indeed, these nucleophiles were condensed onto a series of a,p-unsaturated aldehydes in the presence of 2-[bis(3,5-bistrifluoromethylphenyl)trimethylsilylanyloxymethyl]pyrrolidine as an 

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