Interactions Between Oxygen-Dependent and Other Effector Pathways

6 Interactions Between Oxygen-Dependent and Other Effector Pathways 

Both NO and CO may affect (and be involved in) oxygen-dependent phenomena. Accordingly, in vitro experiments have demonstrated that elevated levels of NO or CO can diminish effects of hypoxia on gene transcription. These molecules both activated the internal oxygen-dependent degradation domain and repressed the C-terminal transactivation domain of HIF resulting in less HIF-la that can bind to DNA (Huang et al., 1999). On the other hand, in vivo experiments have demonstrated that NO is one of the modulators of the hypoxic ventilatory response mediated by the rostral mediolateral medulla (de Paula and Branco, 2003). It is not clear at present, whether different cell types respond in a different manner. 

Oxygen sensors of the peripheral and central nervous systems 

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