Inter- or intramolecular Heck reaction

An indole alkaloid synthesis employing a bona fide intramolecular Heck reaction was documented in Sundberg s preparation of 5,6-homoiboga derivatives [90]. Several attempts to construct S,6-homoiboga derivative 191 using inter- or intramolecular Heck reaction conditions with phosphine ligands led to poor yields. Application of Jeffery s ligand-free" phase-transfer... 

M. Lautens has also reported a tandem process in which a palladium-catalyzed amine vinylation is coupled with an inter- or intramolecular Heck reaction.121 This gives... 

Recent studies show that Ni(0) catalyst is effective for the inter- or intramolecular Heck reaction leading to carbon-carbon bond formation [80]. 

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