Intemeuronal communication

Despite the recent advances in molecular biology, the mechanisms of action and the physiological functions of the anandamide system remain obscure. It would appear that the cannabinoid receptors and the anandamides reside within the neurons. Thus unlike the classical neurotransmitters noradrenaline and serotonin, the anandamides are not released into the synaptic cleft and are not involved in intemeuronal communication. Instead the anandamides modulate the excitability and inhibitory responsiveness of neurons by acting on cannabinoid hetero-ceptors located on inhibitory and excitatory terminals. In this way, the... 

Chivet M, Javalet C, Hemming F, et al. Exosomes as a novel way of intemeuronal communication. Biochem Soc Trans. 2013 41(l) 241-244. 

Vincent P, Marty A (1993) Neighbouring cerebellar Purkinje cells communicate via retrograde inhibition of common presynaptic intemeurons. Neuron 11 885-893. 

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