Intelligence, modification

The attraction for research chemists lies, of course, not in further perfections of the machine — let this be done systematically by the manufacturers — but in intelligent modifications of the target molecules. Examples are given in section 5.1. 

This type of information about a homologous series of drug candidates, when considered in light of the propensity of these compounds to undergo first-pass metabolism and/or liver clearance, allows pharmaceutical scientists to make more intelligent decisions about which compounds to move into animal studies. In addition, when an in vitro-in vivo correlation can be demonstrated for a series of compounds, the results of Caco-2 experiments can be used as a guide by medicinal chemists to make structural modifications to optimize oral bioavailability. 

These two actions by the computer are key to the success of this project. This is because it will be impossible for a human to consider all the possibilities of a large data set and to deduce the best (most simple and therefore cost effective) rules to use in order to choose the best protective materials to use. And when the data base is dynamically growing it would be impossible to use a highly structured artificial intelligence system where the user had to rewrite the program modifications himself every time there was a change in the information. 

As biochemical tools, suitable and sensible imino sugar modifications will certainly become helpful intelligent probes and reporters addressing some of the future needs of research in carbohydrate-active enzymes. 

It is possible after some adaptation and modification to link such apparatuses to bioreactors ( intelligent analytical subsystems ). This trend towards increased automation is not restricted to chromatographic methods (cf. FIA). 

Automating the conceptual design of chemical processes offers significant benefits, such as quick evaluation of many alternative chemical production routes efficient development of economic, operable, and safe processes intelligent documentation of the design process and its rationale, as well as invaluable accumulation of past experience and easy verification and modification of past designs. 

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