Integration of Surrogate Data and Estimations with Physiological Simulation

5 Integration of Surrogate Data and Estimations with Physiological Simulation 

A recent EDA white paper entitled Challenge and Opportunity on the Critical Path to New Medical Products (PDA, March 2004) states that We need to make the effort required to create better tools for developing medical technologies , and ...there is hope that greater predictive power may be obtained from in silico (computer modeling) analyses. ... Some believe that extensive use of in silico technologies could reduce the overall cost of drug development by as much as 50 percent . 

In the preceding sections of this chapter, we have discussed numerous biophar-maceutical properties and methods, which have the potential to deliver a mind-numbing avalanche of data. Simple databases and tables of properties combined with simple rules like the Rule-Of-Five do not provide the platform or integration-of-information needed to make decisions. 

Todeschini and V. Consonni, Handbook of Molecular Descriptors, Wiley-VCH, Verlag GmbH, D-69469 Weinheim, Germany, 2000. 

The Fix-Point Approach to Interdependent Systems, North-Holland, Amsterdam, North Holland, 1981. 

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