Thiazides Insulin

Digitalis glycosides in presence of heart block Thiazide diuretics Exchange resins, sodium cycle Insulin... 

Carbohydrate intolerance is caused by those diuretics which produce prolonged hypokalaemia, i.e. the loop and thiazide type. It appears that intracellular potassium is necessary for the formation of insulin, and glucose intolerance is probably due to insulin deficiency. Insulin requirements thus increase in established diabetics and the disease may become mainifest in latent diabetics. The effect is generally reversible over several months. 

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