Insulin Sensitizers Emerging Therapeutics

BHUVID Research Laboratory Ahmedabad, Gujarat, India 

Drug Discovery and Development, Volume 2 Drug Development, Edited by Mukund S. Chorghade Copyright 2007 John Wiley Sons, Inc. 

Inhibitors of glucose uptake, such as glucosidase inhibitors (e.g., acarbose, voglib-ose), and sodium-glucose transporter (SGLT) inhibitors 

Enhancers of insulin action, such as peroxisome proliferator-activated receptor (PEAR) ligands [e.g., troglitazone (withdrawn from clinical use), pioglitazone, rosi-glitazone], retinoid X receptor (RXR) modulators, and protein tyrosine phosphatase IB (PTP IB) inhibitors 

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INSULIN SENSITIZERS EMERGING THERAPEUTICS TABLE 19.3 Continued)... 

Drs. Braj and Vidya Lohray elaborate on the role of insulin sensitizers in emerging therapeutics. A noteworthy feature of this work is that it was done entirely in India and represents a fast-growing trend the discovery of new chemical entities in that country. 

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