Insulin from polymer microparticles

The protein-polymer microcapsules can be obtained by supercritical anti-solvent techniques [8]. Homogeneous protein-polymer mixtures were contacted with supercritical carbon dioxide in order to produce microspheres with diameter ranging from 1 to 5 pm and containing around 80% of protein. Production of PLA microparticles containing insulin, lysozyme, and chemotrypsin is claimed. SAS crystallization of a pharmaceutical (naproxen) and a biodegradable poly(L-lactic acid) was reported [8]. The results from SAS studies showed very small spherical particles... 

MWCNT electrodes have been developed to monitor the electrochemical oxidation of insulin, a pancreas-produced hormone that plays a key role in the regulation of carbohydrates and fat metabolism in the body. This provides a possible method to evaluate the quality of pancreatic islets before their transplantation. By coating similar MWCNT electrodes with platinum microparticles, thiols containing amino acids can be detected in rat striatal that is the subcortical part of the fore-brain. CNT-based sensors can be incorporated into flexible biocompatible substrates to facilitate in vivo sensing. For instance, free cholesterol in blood can be measured using MWCNT electrodes placed on a biocompatible substrate whereas flexible pH sensors can be formed from polyaniline (a conductive polymer) and nanotube composites. ... 

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