Insulin Botulinum neurotoxin

Howard BD, Gundersen CBJ (1980) Effects and mechanisms of polypeptide neurotoxins that act presynaptically. Annu Rev Pharmacol Toxicol 20 307-36 Huang X, Wheeler MB, Kang YH, Sheu L, Lukacs GL et al. (1998) Truncated SNAP-25 (1-197), like botulinum neurotoxin A, can inhibit insulin secretion from HIT-T15 insulinoma cells. Mol Endocrinol 12 1060-70... [Pg.162]

Boyd RS, Duggan MJ, Shone CC, Foster KA (1995 b) The effect of botulinum neurotoxins on the release of insulin from insulinoma cell lines HIT-15 and RINm5F. In J. Biol. Chem. 270 18216-8... [Pg.187]

Albumin alpha(l)-acid glycoprotein Albumin lysozyme ribonuclease a Amyloid precursor protein Beta lactoglobulin Botulinum neurotoxin Erythropoietin Erythropoietin Hemoglobin variants, mouse Hemoglobin variants, human Hemoglobin, globin chains HIV-1 reverse transcriptase Insulin trypsin... [Pg.90]

The t-SNARE SNAP-25 is also expressed in the P-cell and has been localized mainly to the plasma membrane (Sadoul etal., 1995). SNAP-25 was cleaved by treatment of SLO-permeabilized cells with botulinum toxins (BoNT) A or E. The two neurotoxins inhibited Ca "-induced insulin exocytosis but failed to abolish the process completely (Sadoul ef al., 1995). This could be due to the failure of the toxins to cleave SNAP-25 already complexed to other fusion proteins (escaping detection by Western blotting) or to the requirement for SNAP-25 at a penultimate step in insulin exocytosis. [Pg.220]

Big Chemical Encyclopedia