Inspissated bile syndrome

In a small proportion of cases of hemolytic disease of the newborn (inspissated bile syndrome), large amounts of conjugated bilirubin as well as free bilirubin accumulate in the plasma due to obstruction (J3, L2, S16). Conjugated bilirubin is apparently nontoxic to the brain so that exchange transfusions in such infants are indicated only if the free bilirubin and not the total bile pigment concentration is rising above 20 mg/100 ml plasma. 

Biliaiy tract Inspissated bile syndrome has been attributed to cefotaxime in a neonate [60 ]. 

Miloh T, Rosenberg HK, Kochin I, Kerkar N. Inspissated bile syndrome in a neonate treated with cefotaxime sonographic aid to diagnosis, management, and follow-up. J Ultrasound Med 2009 28(4) 541-4. 

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