Inositols dideoxy

CN 3,4-dideoxy-4-[[2-hydroxy-l-(hydroxymethyl)ethyl]amino]-2-C-(hydroxymethyl)-D-epi-inositol... 

An interesting example of the effectiveness of different reagents for 0-nitration can be seen during the synthesis of neo-inositol-based nitrate ester explosives. l,4-Dideoxy-l,4-dinitro-neo-inositol (15), a compound readily prepared from the condensation of nitromethane and glyoxal in the presence of base,undergoes conversion to the tetranitrate ester (16) on... 

This enzyme [EC 2.1.4.2] catalyzes the reaction of arginine with l-amino-l-deoxy-xcyZ/o-inositol 4-phosphate to produce ornithine and l-guanidino-l-deoxy-scy//o-inositol 4-phosphate. Other substrates include lo-l-gua-nidino-3-amino-l,3-dideoxy-xcy//o-inositol 6-phosphate, streptamine phosphate and 2-deoxystreptamine phosphate. Canavanine can substitute for arginine. 

Oppong KA, Hudlicky T, Yan F, York C, Nguyen BV (1999) Chemoenzymatic Enantio-divergent Synthesis of l,2-Dideoxy-2-amino-l-fluoro-a//o-inositol. Tetrahedron 55 2875... 

Chemical Name L-chiro-Inositol, 4-amino-l-((aminoacetyl)methylamino)-l,4-dideoxy-3-0-(2,6-diamino-2,3,4,6,7-pentadeoxy-p-L-lyxo-heptopyranosyl)-6-0-methyl-, sulfate (1 2)... 

Deoxy-chiro-inositol 1,2-0-Isopropylidene-4-C-methyl-4-nitro- E21b, 1791 (0-SiR3-6,7-dideoxy— 2,3-O-isopropyli-den — 6-N 02 — heptofuranoside/ R4NF)... 

SYNS ANTIBIOTIC SF2052 SULFATE 1-CHIRO-INOSITOL, 4-AMINO-l,4-DIDEOXY-3-o-(2,6-DIAMINO-2,3,4,6,7-PENTADEOXY-P-l-LYXO-HEPTOPYRANOSYL)-6-o-METHYL-l -(2-(FORMIMIDOYLAMINO)-N-METHYL-ACETAMIDO)-, SULFATE (1 2),HYDRATE SF-2052 SULFATE... 

A number of tetraphosphate analogues, e.g. 24, have been prepared with a view to increasing cell membrane permeation properties. Routes to 3,4,5,6-tetrakis-phosphates, e.g. 25, of DL-l,2-dideoxy-l,2-difluoro-mjo-inositol and dl-1,2-dideoxy-1,2-difluoro-5cj//o-inositol have been reported.The fluoro substituents were introduced using DAST to displace hydroxy groups. However, the difluorina-tion could not be achieved in one step due to competing formation of a 1,4-anhydro derivative. The synthesis, from wjo-inositol monobenzoate derivatives, of all four... 

Of especial interest is the extremely facile dehydroacetylation of structures that contain a nitro group flanked on both sides by acetoxyl groups. Deoxynitroinositol pentaacetates (185 and epimers) and 1,4-dideoxy-l,4-dinitro-neo-inositol tetraacetate (187) readily lose three molecules of acetic acid per molecule by the action of pyridine, to... 

ATP -I- lD-l-guanidino-3-amino-l,3-dideoxy-scyZ/o-inositol <1> (Reversibility <1> [2]) [2]... 

---