Innate releaser mechanism

In two-factor theory, hungers and other appetites must be elicited by stimuli that are outside of the person s control. If the theory s other assumptions were true, this tenet would be both possible and necessary. It would be possible because two-factor theory holds appetites to be special kinds of processes that initially depend on innate releasing stimuli but that can come to be elicited by arbitrary cues through pairing alone. It would be necessary in the case of aversive appetites, because, with conventional exponential discounting, there is no other mechanism to make a person generate them. The easiest cure for fear... 

Glucocorticoids (GC) produced endogenously in response to stress alter both innate and antigen-driven immunity. Cortisol (hydrocortisone) is the predominant GC in humans and most other species, whereas corticosterone is the most plentiful in mice and rats. Both natural and synthetic GC are used to reduce inflammation, manage autoimmune and hypersensitivity diseases, and treat certain neoplastic diseases. Certain inflammatory cytokines, including IL-1, IL-6 and TNFa stimulate (directly and indirectly) GC synthesis and release, a feedback mechanism to control inflammation. 

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