Injected fluids, premature

The second condition is that the fluid pressure must remain high enough to keep the hole in the skin open and avoid the elastic forces that tend to cause resealing. This pressure is on the order of a few megapascals, and so premature resealing is only likely to occur for devices that exhibit a substantial pressure reduction near the end of the injection. 

In vivo fiber-based spectroscopic analysis of tissues has been shown to offer a valuable tool to orient and facilitate medical diagnostics [169,170]. Hocde et al. used FEWS to identify metabolic alterations in laboratory animals [136]. For this the authors compared the spectral trace of biological fluid serums extracted from the blood samples of healthy and obese mice. FEWS has been successfully used to control in real time the glucose levels of human patients after they received intravenous glucose injections [171]. Noninvasive measurements were performed through the mucous membrane of the lips of a patient, a promising result for diabetes control. Similar FEWS in vivo measurements have been carried out on anesthetized live animals for premature tumor detection [167]. 

---