Injectable products design

Intravenous aqueous injections provide an excellent means of achieving a rapid therapeutic response. Parenteral product design, eg, vehicle and other excipient selection, as well as choice of route of adrninistration, can prolong therapeutic activity and increase onset times. Thus, oily solutions, suspensions, or emulsions can be adrninistered by subcutaneous or intramuscular routes to create prolonged effect, ie, depot injection (28). 

An example of such a product is Sterile Medroxyprogestrone Acetate Suspension used for its contraceptive property. Such an injection is designed to provide up to three months of contraceptive activity. Another such product is a depot injection of leuprolode acetate, an analogue of gonadatropin-releasing hormone (see Drug delivery systems). In this case, the product is a sterilized powder of microspheres to be suspended upon the addition of an appropriate diluent and intended for monthly injection. 

MOLDEST Provides product design, mold design, and injection molding process control by Fujitsu Ltd., Tokyo, Japan. 

In addition to the process parameters, there are large numbers of factors that decide the success of an injection molding operation. Mold design, product design, position, and size of gates, type and positioning of runners, etc., are extremely important factors to be taken care of. A detail consideration regarding these factors has been discussed below [213]. 

Design Specifications for Water for Injection Production and Distribution... 

Parenteral Dosage Forms. The most commonly used forms for drug products designed and manufactured for injection through the skin include those meant for subcutaneous, intramuscular, and intravenous administration. 

FIGURE 14-43 A commercial injection mold for construction cones (Courtesy Product Design Inc.). 

The plant is designed to produce oral solid dosage forms as well as liquid dosage forms, ointments, creams, suppositories, and sterile injectable products. 

The level of information on the dosage form and pack should provide sufficient clarity of detail to enable the Pharmaceutical Development group to plan their development. These pharmaceutical attributes may be documented separately in a pharmaceutical product profile . A typical example of a pharmaceutical product profile is shown in Table 5.2 for an intravenous injection product, illustrating the level of detail expected in a Product Design Report. 

---