Injectable polymers Poloxamer

Muller RH, Wallis KH (1993) Surface modification of i.v. injectable biodegradable nanoparticles with poloxamer polymers and poloxamine 908. Int. J. Pharm. 89 25-31. 

Thennosensitive polymers have been developed extensively over the past years l-4. In particular, polymers showing a sol-gel transition by temperature change have been proposed for an injectable drug delivery depot [5,6]. As an example of temperature sensitive polymers, aqueous solutions of commercially available poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO Pluronics (BASF) or Poloxamers (ICI)) demonstrated sol-gel phase transitions with increasing temperature. 

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