Initiated by Addition of C-Nucleophile to Ruthenium Vinylidene

Carbocyclization Initiated by Addition of C-Nucleophile to Ruthenium Vinylidene 

As terminal alkynes and ethynyl alcohols are the convenient sources to generate ruthenium vinylidene and allenylidene intermediates, many carbocyclizations have been achieved via nucleophilic addition and other activations at the two intermediates. Most reported carbocyclizations appear to be synthetically useful, not only because of their chemoselectivities but also because of their tolerance toward organic functional groups. Additional examples of catalytic carbocyclization based on ruthenium vinylidenes are still growing, and on the basis of the concepts developed here one can expect to see many new applications in the near future. 

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For recent reviews, see Bruneau, C. and Dixneuf, P.H. (2006) Angewandte Chemie-International Edition, 45, 2176. (b) Bruneau, C. (2004) Topics in Organometallic Chemistry, Vol. 11, (eds C. Bruneau and 

6 (a) Alvarez, P., Lastra, E., Gimeno, )., Bassetti, M. and Falvello, L.R. (2003) Journal of the American Chemical Society, 

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