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Inhibition of hepatic glucose production

In t3 e 2 diabetes, hepatic glucose production is increased [113]. A possible way to suppress hepatic glucose production and lower blood glucose in type 2 diabetes patients may be through inhibition of hepatic glycogen phosphorylase [114]. In enzyme assay, Fosgerau et al. reported... [Pg.1903]

The mechanism by which glucose production in the liver is elevated in Type-II diabetes is unclear. It is conceivable that it is the result of decreased sensitivity to insulin. Nevertheless, compounds that inhibit hepatic glucose production/output may also be potential antidiabetic drugs. [Pg.180]

Insulin lowers the concentration of glucose in blood by inhibiting hepatic glucose production and by stimulating the uptake and metabohsm of glucose by muscle and adipose tissue (Table 60-1). These two important effects occur at different concentrations of insuhn. Glucose production is inhibited half maximally by an insuhn concentration of about 20 /mnits/mL, whereas glucose uthization is stimulated half maximally at about 50 /runits/mL. [Pg.1041]

Inhibition of these reactions prevents hepatic glucose production resulting in hypoglycaemia. [Pg.53]


See other pages where Inhibition of hepatic glucose production is mentioned: [Pg.295]    [Pg.65]    [Pg.1019]    [Pg.288]    [Pg.744]    [Pg.744]    [Pg.297]    [Pg.359]    [Pg.360]    [Pg.365]    [Pg.368]    [Pg.295]    [Pg.65]    [Pg.1019]    [Pg.288]    [Pg.744]    [Pg.744]    [Pg.297]    [Pg.359]    [Pg.360]    [Pg.365]    [Pg.368]    [Pg.100]    [Pg.226]    [Pg.96]    [Pg.542]    [Pg.57]    [Pg.294]    [Pg.754]    [Pg.487]    [Pg.487]    [Pg.196]    [Pg.349]    [Pg.128]    [Pg.1021]    [Pg.1023]    [Pg.293]    [Pg.133]    [Pg.23]    [Pg.739]    [Pg.209]    [Pg.33]    [Pg.224]    [Pg.234]    [Pg.307]    [Pg.1041]    [Pg.365]    [Pg.57]    [Pg.231]    [Pg.320]    [Pg.3815]    [Pg.212]    [Pg.152]    [Pg.104]    [Pg.127]    [Pg.548]    [Pg.590]   
See also in sourсe #XX -- [ Pg.361 , Pg.366 , Pg.368 ]




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Glucose production

Glucose products

Hepatic glucose production

Hepatic production

Product inhibition

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