Inhibition of Cytoplasmic Membranes

Lipids, lipoproteins, and proteins makeup cytoplasmic membranes. This membrane is a diffusion barrier for ions, nutrients, transport systems, and most importantly, water. It is composed of a lipid grouping with globular proteins that penetrate the lipid bilayer. Most antibacterial agents that inhibit cytoplasmic membranes do so by influencing the balance of cations, anions, or neutral compounds, thus disrupting membrane operation. Of interest is that fungal 

Antibacterial agents can interfere with nucleic acid synthesis at a number of junctures including replication and/or transcription of DNA through preferential binding or insertion into the DNA. They may also influence the proteins involved with the replication. Other antibacterial agents interfere with the RNA synthesis, action, or proteins associated with these functions. They may also interfere with the coiling and uncoiling necessary for appropriate action. 

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