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Inhalation administration irritation testing

Administration of large doses of quinone to experimental animals caused local irritation, clonic convulsions, respiratory difficulties, drop in blood pressure, and death due to paralysis of the medullary centers. In chronic studies, quinone has been tested in mice by skin application and inhalation and in rats by subcutaneous injection. The lARC has determined that there is inadequate evidence in experimental animals for carcinogenicity of quinone and that it is not classifiable as to its carcinogenicity to humans. ... [Pg.614]

Propionaldehyde is a mild irritant to human skin and eyes. The irritation effect from 40 mg was severe in rabbits eyes. The toxicity of this compound observed in test animals was low. Subcutaneous administration in rats exhibited the symptoms of general anesthetic effect, convulsion, and seizure. Inhalation toxicity was determined to be low. A concentration of 8000 ppm (19,000 mg/m ) in air was lethal to rats. [Pg.172]

See other pages where Inhalation administration irritation testing is mentioned: [Pg.1112]    [Pg.332]    [Pg.499]    [Pg.507]    [Pg.158]    [Pg.491]    [Pg.499]    [Pg.666]    [Pg.688]    [Pg.1079]    [Pg.70]    [Pg.57]    [Pg.263]    [Pg.341]    [Pg.651]    [Pg.559]   


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Inhalation administration

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Inhaled irritants

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